| | Runs | playerId | seasonId | clubId | matchId | Runs | Player | Team | Season | Grade | Round | Inns | Opponent |
| 1 | 141 | 36489 | 155 | 402 | 3852446 | 141* | Daniel Salpietro | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 5 | 1 | Sunshine |
| 2 | 120 | 1060311 | 155 | 402 | 3852452 | 120 | Dinesh R Cooray | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 10 | 1 | PEGS |
| 3 | 110 | 36489 | 155 | 402 | 3852443 | 110 | Daniel Salpietro | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 2 | 1 | Seddon |
| 4 | 105 | 1060311 | 155 | 402 | 3852449 | 105 | Dinesh R Cooray | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 7 | 1 | West Coburg |
| 5 | 103 | 16368 | 155 | 402 | 4050141 | 103* | David Fox | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | QF | 1 | Preston Druids |
| 6 | 102 | 5842 | 155 | 402 | 3964976 | 102* | Adrian Totino | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 11 | 1 | Oak Park |
| 7 | 101 | 16367 | 155 | 402 | 3964964 | 101* | Jon Clampett | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 8 | 1 | Preston Druids |
| 8 | 101 | 16368 | 155 | 402 | 3964970 | 101* | David Fox | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 9 | 1 | Sunshine Heights - Western Stars |
| 9 | 100 | 1060311 | 155 | 402 | 4057505 | 100 | Dinesh R Cooray | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 13 | 1 | St Francis de Sales |
| 10 | 99 | 711102 | 155 | 402 | 3857416 | 99 | Benjamin Sims | Airport West St Christophers | 2021/2022 | Bondini / Bannon Shield Div 1 Seconds | 3 | 1 | Altona North |
| 11 | 93 | 5842 | 155 | 402 | 3964971 | 93* | Adrian Totino | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 10 | 1 | Tullamarine |
| 12 | 88 | 36489 | 155 | 402 | 3852442 | 88* | Daniel Salpietro | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 1 | 1 | PEGS |
| 13 | 88 | 182595 | 155 | 402 | 3964961 | 88 | Joe Tornese | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 7 | 1 | Oak Park |
| 14 | 84 | 25960 | 155 | 402 | 4057505 | 84 | Jordon Kelly | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 13 | 1 | St Francis de Sales |
| 15 | 83 | 16336 | 155 | 402 | 4061306 | 83* | Nathan Wilson | Airport West St Christophers | 2021/2022 | Bondini / Bannon Shield Div 1 Seconds | 13 | 1 | St Francis de Sales |
| 16 | 82 | 315981 | 155 | 402 | 3857394 | 82 | Kevin Brittain | Airport West St Christophers | 2021/2022 | Bondini / Bannon Shield Div 1 Seconds | 2 | 1 | Seddon |
| 17 | 81 | 36489 | 155 | 402 | 3852452 | 81 | Daniel Salpietro | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 10 | 1 | PEGS |
| 18 | 79 | 729587 | 155 | 402 | 3964955 | 79 | Ty Macumber | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 6 | 1 | Tullamarine |
| 19 | 75 | 16368 | 155 | 402 | 3964971 | 75 | David Fox | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 10 | 1 | Tullamarine |
| 20 | 70 | 25960 | 155 | 402 | 3852450 | 70 | Jordon Kelly | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 8 | 1 | Deer Park |
| 21 | 66 | 315981 | 155 | 402 | 3857420 | 66 | Kevin Brittain | Airport West St Christophers | 2021/2022 | Bondini / Bannon Shield Div 1 Seconds | 4 | 1 | St Francis de Sales |
| 22 | 64 | 1060311 | 155 | 402 | 3852446 | 64 | Dinesh R Cooray | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 5 | 1 | Sunshine |
| 23 | 61 | 25960 | 155 | 402 | 3852443 | 61 | Jordon Kelly | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 2 | 1 | Seddon |
| 24 | 60 | 315981 | 155 | 402 | 3964970 | 60 | Kevin Brittain | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 9 | 1 | Sunshine Heights - Western Stars |
| 25 | 58 | 16371 | 155 | 402 | 3964961 | 58* | Michael J O'Dwyer | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 7 | 1 | Oak Park |
| 26 | 54 | 36489 | 155 | 402 | 3942615 | 54 | Daniel Salpietro | Airport West St Christophers | 2021/2022 | T20 Round Robin - TAYLOR | 3 | 1 | Keilor |
| 27 | 53 | 1108101 | 155 | 402 | 4003510 | 53* | Lachlan Jones | Airport West St Christophers | 2021/2022 | McCabe Shield 16 A | 3 | 1 | St Albans |
| 28 | 53 | 1108101 | 155 | 402 | 4003511 | 53* | Lachlan Jones | Airport West St Christophers | 2021/2022 | McCabe Shield 16 A | 4 | 1 | Westmeadows |
| 29 | 52 | 1854024 | 155 | 402 | 3944868 | 52* | Brendan Jones | Airport West St Christophers | 2021/2022 | Aub Giddings Shield | 3 | 1 | Strathmore (2) |
| 30 | 52 | 2203283 | 155 | 402 | 3944868 | 52* | Ben Ditfort | Airport West St Christophers | 2021/2022 | Aub Giddings Shield | 3 | 1 | Strathmore (2) |
| 31 | 52 | 16368 | 155 | 402 | 3964964 | 52 | David Fox | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 8 | 1 | Preston Druids |
| 32 | 52 | 36489 | 155 | 402 | 4062320 | 52 | Daniel Salpietro | Airport West St Christophers | 2021/2022 | Deer Park Club / Isaacs Howarth Shield Division 1 | 12 | 1 | Altona North |
| 33 | 52 | 1921795 | 155 | 402 | 4003530 | 52* | Jamie Kopp | Airport West St Christophers | 2021/2022 | McCabe Shield 16 A | 10 | 1 | Craigieburn |
| 34 | 52 | 1579907 | 155 | 402 | 3944866 | 52* | Michael Meggs | Airport West St Christophers | 2021/2022 | Aub Giddings Shield | 2 | 1 | Strathmore (1) |
| 35 | 51 | 16336 | 155 | 402 | 3857401 | 51* | Nathan Wilson | Airport West St Christophers | 2021/2022 | Bondini / Bannon Shield Div 1 Seconds | 8 | 1 | Deer Park |
| 36 | 51 | 16368 | 155 | 402 | 3964955 | 51 | David Fox | Airport West St Christophers | 2021/2022 | Andrew Knight Shield | 6 | 1 | Tullamarine |
| 37 | 51 | 390913 | 155 | 402 | 3944880 | 51* | Peter Wood | Airport West St Christophers | 2021/2022 | Aub Giddings Shield | 7 | 1 | Strathmore (1) |
| 38 | 51 | 16358 | 155 | 402 | 3944878 | 51* | Paul Spicer | Airport West St Christophers | 2021/2022 | Aub Giddings Shield | 6 | 1 | East Keilor |
| 39 | 50 | 1530261 | 155 | 402 | 4068734 | 50* | Rohan Mitchell | Airport West St Christophers | 2021/2022 | Aub Giddings Shield | SF | 1 | Strathmore (1) |
| 40 | 50 | 1925373 | 155 | 402 | 4003511 | 50* | Heath Condon | Airport West St Christophers | 2021/2022 | McCabe Shield 16 A | 4 | 1 | Westmeadows |
| 41 | 50 | 1925373 | 155 | 402 | 4003525 | 50* | Heath Condon | Airport West St Christophers | 2021/2022 | McCabe Shield 16 A | 8 | 1 | Brunswick Cricket Club |
| 42 | 50 | 890919 | 155 | 402 | 4003530 | 50* | D'Arcy Mulcahy | Airport West St Christophers | 2021/2022 | McCabe Shield 16 A | 10 | 1 | Craigieburn |
| 43 | 50 | 1530261 | 155 | 402 | 3944868 | 50* | Rohan Mitchell | Airport West St Christophers | 2021/2022 | Aub Giddings Shield | 3 | 1 | Strathmore (2) |
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